It is a perennial savannah legume shrub or tree, up to 20 m high. It is also found in most parts of Nigeria. It is widely distributed throughout the southern Sahel and Sudan savannah from Senegal to Cameroun, up to Sudan and the Republic of Congo. Keywords: Cassia sieberiana, in vivo, in vitro, Toxicity IntroductionĬassia sieberiana DC ( Caesalpiniaceae) is a very common plant in all Sudanese savannah. The cytotoxicity study on cell viability showed that the plant seems to be cytotoxic only at very high doses. However, the histological study showed the presence of necrotic and inflammatory cells in the hepatic parenchyma and a sinusoidal stasis at the end of 28 days. sieberiana did not result in death among the animals there were no signs of toxicity. The results showed that the acute and subchronic toxicity studies of hydroalcoholic root extract of C. Histological studies of the liver, heart, and kidney tissues were also performed. Urinalysis, haematological and biochemical analyses were carried out on urine, whole blood and serum samples. Each set consisted of 3 males (278 ± 13g) and 3 females (260 ± 10 g). In the sub-chronic toxicity study, the hydroethanolic extract at 500, 10 mg/kg was administered to sets of 6 Wistar rats daily for 28 days. Sieberiana root bark and observed for signs of acute toxicity for 14 days. In the acute toxicity study, five female rats (260 ± 10 g) were each administered a single oral dose (5000 mg/kg) of the hydroethanolic extract of C.

Cytotoxicity of this extract was studied on vervet monkey kidney cells by the MMT method concurrently.

Received: 07 November 2017 Accepted: 21 December 2017 Published: 28 December 2017 AbstractĪcute and sub-chronic toxicity studies of hydroethanolic root extract of Cassia sieberiana (Caesalpiniaceae), a plant widely used in traditional medicine in Senegal, were carried out in Wistar rats.

Acute, Sub-Chronic Toxicity in Wistar Rats and Cytotoxicity Studies of Hydroethanolic Root Extract of Cassia Sieberiana DC. Published by Scientific Open Access Journals LLC.Ĭitation: Fatoumata B, Yaghouba K, Dior FA, et al. Research Article | J Toxic Pharm 2017 1:017 | Open AccessĪcute, Sub-Chronic Toxicity in Wistar Rats and Cytotoxicity Studies of Hydroethanolic Root Extract of Cassia Sieberiana DCīAH Fatoumata 1, KANE Yaghouba 2, FALL Alioune Dior 3, CABRAL Mathilde 1, TOURE Aminata 1, LAM-FAYE Absa 1, DIOP Cheikh 1, DIENG Serigne Ibra Mbacke 3, DIOUF Amadou 1 and FALL Mamadou 1*ġLaboratoire de Toxicologie et Hydrologie, Université Cheikh Anta Diop, Dakar, SenegalĢService de Pathologie médicale, d’anatomie pathologique et clinique ambulante à l’Ecole Inter-états des Sciences et Médecine Vétérinaires de Dakar (E.I.S.M.V.)ģLaboratoire de Pharmacognosie et de Botanique, Université Cheikh Anta Diop, Dakar, Senegal

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